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1.
Sensors (Basel) ; 23(11)2023 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-37299921

RESUMO

Vehicular communication systems can be used to enhance the safety level of road users by exchanging safety/warning messages. In this paper, an absorbing material on a button antenna is proposed for pedestrian-to-vehicle (P2V) communication, which provides safety service to road workers on the highway or in a road environment. The button antenna is small in size and is easy to carry for carriers. This antenna is fabricated and tested in an anechoic chamber; it can achieve a maximum gain of 5.5 dBi and an absorption of 92% at 7.6 GHz. The maximum distance of measurement between the absorbing material of the button antenna and the test antenna is less than 150 m. The advantage of the button antenna is that the absorption surface is used in the radiation layer of the antenna so that the antenna can improve the radiation direction and gain. The absorption unit size is 15 × 15 × 5 mm3.


Assuntos
Automóveis , Pedestres , Humanos , Desenho de Equipamento/instrumentação , Desenho de Equipamento/métodos
2.
Int J Pharm ; 637: 122888, 2023 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-36977451

RESUMO

Microneedle-based technologies are the subject of intense research and commercial interest for applications in transdermal delivery and diagnostics, primarily because of their minimally invasive and painless nature, which in turn could lead to increased patient compliance and self-administration. In this paper, a process for the fabrication of arrays of hollow silicon microneedles is described. This method uses just two bulk silicon etches - a front-side wet etch to define the 500 µm tall octagonal needle structure itself, and a rear-side dry etch to create a 50 µm diameter bore through the needle. This reduces the number of etches and process complexity over the approaches described elsewhere. Ex-vivo human skin and a customised applicator were used to demonstrate biomechanical reliability and the feasibility of using these microneedles for both transdermal delivery and diagnostics. Microneedle arrays show no damage even when applied to skin up to 40 times, are capable of delivering several mL of fluid at flowrates of 30 µL/min, and of withdrawing 1 µL of interstitial fluid using capillary action.


Assuntos
Desenho de Equipamento , Agulhas , Silício , Humanos , Administração Cutânea , Sistemas de Liberação de Medicamentos/instrumentação , Microinjeções/instrumentação , Microinjeções/métodos , Reprodutibilidade dos Testes , Pele , Indústria Manufatureira , Desenho de Equipamento/métodos
3.
Small Methods ; 6(2): e2101051, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35174985

RESUMO

Electrode microfabrication technologies such as lithography and deposition have been widely applied in wearable electronics to boost interfacial coupling efficiency and device performance. However, a majority of these approaches are restricted by expensive and complicated processing techniques, as well as waste discharge. Here, helium plasma irradiation is employed to yield a molybdenum microstructured electrode, which is constructed into a flexible piezoresistive pressure sensor based on a Ti3 C2 Tx nanosheet-immersed polyurethane sponge. This electrode engineering strategy enables the smooth transition between sponge deformation and MXene interlamellar displacement, giving rise to high sensitivity (1.52 kPa-1 ) and good linearity (r2  = 0.9985) in a wide sensing range (0-100 kPa) with a response time of 226 ms for pressure detection. In addition, both the experimental characterization and finite element simulation confirm that the hierarchical structures modulated by pore size, plasma bias, and MXene concentration play a crucial role in improving the sensing performance. Furthermore, the as-developed flexible pressure sensor is demonstrated to measure human radial pulse, detect finger tapping, foot stomping, and perform object identification, revealing great feasibility in wearable biomonitoring and health assessment.


Assuntos
Desenho de Equipamento/métodos , Determinação da Frequência Cardíaca/instrumentação , Dispositivos Eletrônicos Vestíveis , Análise de Elementos Finitos , Humanos , Microtecnologia , Poliuretanos/química , Titânio/química , Tato
4.
PLoS One ; 17(2): e0264181, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35192654

RESUMO

Low-power consumption has been always a crucial design constraint for an efficient intellectual property based three-dimensional multi-core system that cannot be ignored easily. As the complexity increases due to the number of cores/stacks/ layers in 3D digital systems, the challenges to handle power can be more difficult at a high abstraction level. Therefore, the low-power approach gives designers an opportunity to estimate and optimize the power consumption in the early stages of design phases. The accurate power estimation through the macro-modeling approach at high-level reduces the risk of redesign cycle and turn-around time. In this research, we have presented an improved statistical macro-modeling approach that estimates power through statistical characteristics of randomly generated input patterns by using Biogeography Based Optimization. These input patterns propagate signals into an IP-based 3D digital test system. In experiments, the test system is based on four 8 to 32- bits heterogeneous cores. The response of the power is monitored by applying the well-known Monte Carlo Simulation technique. The entire power estimation method is performed in two major steps. First, the average power is estimated for an IP-based individual core. Second, the average power for bus-based Through-Silicon-Via is estimated. Finally, the cores and B-TSVs are integrated together to construct a 3D system. Then the average power for complete test systems is estimated. The experimental results of the statistical power macro-model are compared with the commercial Electronic Design Automation power simulator at the operating frequency of 100 MHz. The average percentage error of the test system is calculated as 8.65%. For the validation of these results, the statistical error analysis is additionally performed and reveals that our proposed macro-model is accurate in terms of percentage of error with a feasible amount of time.


Assuntos
Desenho de Equipamento/métodos , Modelos Teóricos , Transistores Eletrônicos , Simulação por Computador , Humanos
5.
PLoS One ; 17(1): e0262365, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35085291

RESUMO

Power quality issues, which are mainly due to power electronic devices that are invariably used not only in domestic sector but also industries, still persist despite various mitigation strategies. The slow but steady invasion of Electric vehicles or Plug-in Electric Vehicles (PEVs) in recent years, in the automobile sector, adds woes to the power quality issues further. Majority of the charging systems presently available for charging PEVs are unidirectional and so supports Grid to Vehicle (G2V) mode only as the bidirectional integration of those vehicles into the grid is still a big challenge. However, Vehicle to Grid (V2G) support mode also deserves an equal importance as the PEV charger with V2G mode of operation is capable of supporting grid functionalities also, on need basis, which largely depends on the power circuit topology and controller topology it uses. Hence, in this work an improved controller topology has been designed and developed to alleviate the burdens on the grid. Support for active power demand, voltage swell and sag mitigation, in addition to catering its prime objective of charging the batteries are focused. A Second Order Generalized Integrator Phase Locked Loop (SOGI-PLL) based controller has been developed and implemented in the proposed work to improve the transient response, apart from controlling the steady-state oscillations of the grid to which it is connected to. A single phase non-isolated bidirectional PEV charger with proposed control topology has been simulated in MATLAB-Simulink for vehicle support and grid support mode of operations. The simulation proves the satisfactory operation of the proposed charger in the four quarters of active power and reactive power (PQ) plane, thus complies the design objectives of bidirectional power flow. The results obtained from the simulation show improved performance in terms of DC link voltage overshoot, steady-state oscillations, overall efficiency, voltage and current Total Harmonic Distortions (THD).


Assuntos
Desenho de Equipamento/métodos , Algoritmos , Automóveis , Simulação por Computador , Sistemas Computacionais , Fontes de Energia Elétrica , Eletricidade , Eletrodos
6.
Prenat Diagn ; 42(2): 164-171, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35048376

RESUMO

OBJECTIVES: To develop and test a novel vesicoamniotic shunt (VAS) to treat fetal lower urinary tract obstruction (LUTO), decrease dislodgement and optimize shunt deployment in-vitro. METHODS: Vesicoamniotic shunt design objectives included: (1) robust and atraumatic fixation elements, (2) kink resistant conduit to adjust to fetal movement and growth, (3) one-way pressure valve to facilitate bladder cycling, and (4) echogenic deployment visualization aids. The force to dislodge the novel Vortex shunt was compared with existing commercially available shunts in a bench-top porcine bladder model. Sonographic echogenicity was evaluated with ultrasound-guided deployment, and the shunt valve pressure measured. RESULTS: A prototype novel Vortex shunt was developed using braided nitinol "umbrella-type" ends with a kink-resistant stem incorporating an internal one-way valve. The peak force required to dislodge the Vortex shunt was significantly higher than commercially available shunts (p < 0.01). Shunt deployment in the bench-top model was easily confirmed with ultrasound guidance and the brisk decompression of the inflated porcine bladder thereafter. In-vitro valve gauge pressure testing mirrored bladder pressures in human LUTO cases. CONCLUSION: In-vitro testing shows that the Vortex shunt may improve deployment, sonographic visualization, kink resistance, and dynamic size adjustment. Validation in preclinical animal models are warranted and currently underway.


Assuntos
Desenho de Equipamento/métodos , Doenças Fetais/cirurgia , Terapias Fetais/instrumentação , Obstrução Uretral/cirurgia , Procedimentos Cirúrgicos Urológicos/instrumentação , Anastomose Cirúrgica/instrumentação , Anastomose Cirúrgica/métodos , Animais , Feminino , Terapias Fetais/métodos , Técnicas In Vitro , Gravidez , Suínos , Procedimentos Cirúrgicos Urológicos/métodos
7.
Adv Sci (Weinh) ; 9(1): e2103277, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34723442

RESUMO

Variable stiffness catheters are typically composed of an encapsulated core. The core is usually composed of a low melting point alloy (LMPA) or a thermoplastic polymer (TP). In both cases, there is a need to encapsulate the core with an elastic material. This imposes a limit to the volume of variable stiffness (VS) material and limits miniaturization. This paper proposes a new approach that relies on the use of thermosetting materials. The variable stiffness catheter (VSC) proposed in this work eliminates the necessity for an encapsulation layer and is made of a unique biocompatible thermoset polymer with an embedded heating system. This significantly reduces the final diameter, improves manufacturability, and increases safety in the event of complications. The device can be scaled to sub-millimeter dimensions, while maintaining a high stiffness change. In addition, integration into a magnetic actuation system allows for precise actuation of one or multiple tools.


Assuntos
Cateteres , Desenho de Equipamento/métodos , Robótica/métodos , Materiais Inteligentes/química , Humanos
8.
Adv Sci (Weinh) ; 9(1): e2103257, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34713981

RESUMO

Wearable sweat sensors have received significant research interest and have become popular as sweat contains considerable health information about physiological and psychological states. However, measured biomarker concentrations vary with sweat rates, which has a significant effect on the accuracy and reliability of sweat biosensors. Wearable sweat loss measuring devices (SLMDs) have recently been proposed to overcome the limitations of biomarker tracking and reduce inter- and intraindividual variability. In addition, they offer substantial potential for monitoring human body homeostasis, because sweat loss plays an indispensable role in thermoregulation and skin hydration. Previous studies have not carried out a comprehensive and systematic review of the principles, importance, and development of wearable SLMDs. This paper reviews wearable SLMDs with a new health perspective from the role of sweat loss to advanced mechanisms and designs. Two types of sweat and their measurement significance for practical applications are highlighted. Then, a comprehensive review of advances in different wearable SLMDs based on hygrometers, absorbent materials, and microfluidics is presented by describing their respective device architectures, present situations, and future directions. Finally, concluding remarks on opportunities for future application fields and challenges for future sweat sensing are presented.


Assuntos
Técnicas Biossensoriais/métodos , Desenho de Equipamento/métodos , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/métodos , Suor , Dispositivos Eletrônicos Vestíveis , Humanos
9.
Adv Sci (Weinh) ; 9(3): e2102945, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34837353

RESUMO

Peripheral nerves carry sensory (afferent) and motor (efferent) signals between the central nervous system and other parts of the body. The peripheral nervous system (PNS) is therefore rich in targets for therapeutic neuromodulation, bioelectronic medicine, and neuroprosthetics. Peripheral nerve interfaces (PNIs) generally suffer from a tradeoff between selectivity and invasiveness. This work describes the fabrication, evaluation, and chronic implantation in zebra finches of a novel PNI that breaks this tradeoff by interfacing with small nerves. This PNI integrates a soft, stretchable microelectrode array with a 2-photon 3D printed microclip (µcPNI). The advantages of this µcPNI compared to other designs are: a) increased spatial resolution due to bi-layer wiring of the electrode leads, b) reduced mismatch in biomechanical properties with the nerve, c) reduced disturbance to the host tissue due to the small size, d) elimination of sutures or adhesives, e) high circumferential contact with small nerves, f) functionality under considerable strain, and g) graded neuromodulation in a low-threshold stimulation regime. Results demonstrate that the µcPNIs are electromechanically robust, and are capable of reliably recording and stimulating neural activity in vivo in small nerves. The µcPNI may also inform the development of new optical, thermal, ultrasonic, or chemical PNIs as well.


Assuntos
Eletrodos Implantados , Desenho de Equipamento/métodos , Microeletrodos , Nervos Periféricos/fisiologia , Impressão Tridimensional , Animais , Tentilhões , Masculino , Modelos Animais
10.
Adv Sci (Weinh) ; 9(3): e2103714, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34791832

RESUMO

In flexible electronics, appropriate inlaid structures for stress dispersion to avoid excessive deformation that can break chemical bonds are lacking, which greatly hinders the fabrication of super-foldable composite materials capable of sustaining numerous times of true-folding. Here, mimicking the microstructures of both cuit cocoon possessing super-flexible property and Mimosa leaf featuring reversible scatheless folding, super-foldable C-web/FeOOH-nanocone (SFCFe) conductive nanocomposites are prepared, which display cone-arrays on fiber structures similar to Mimosa leaf, as well as non-crosslinked junctions, slidable nanofibers, separable layers, and compressible network like cuit cocoon. Remarkably, the SFCFe can undergo over 100 000 times of repeated true-folding without structural damage or electrical conductivity degradation. The mechanism underlying this super-foldable performance is further investigated by real-time scanning electron microscopy folding characterization and finite-element simulations. The results indicate its self-adaptive stress-dispersion mechanism originating from multilevel biomimetic structures. Notably, the SFCFe demonstrates its prospect as a super-foldable anode electrode for aqueous batteries, which shows not only high capacities and satisfactory cycling stability, but also completely coincident cyclic voltammetry and galvanostatic charge-discharge curves throughout the 100 000 times of true-folding. This work reports a mechanical design considering the self-adaptive stress dispersion mechanism, which can realize a scatheless super-foldable electrode for soft-matter electronics.


Assuntos
Condutividade Elétrica , Eletrodos , Eletrônica/métodos , Desenho de Equipamento/métodos , Nanocompostos/química , Nanofibras/química
11.
World Neurosurg ; 157: e40-e48, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34583006

RESUMO

OBJECTIVE: To compare cement distribution and leakage for 2 bone cement-augmented screws with different designs of injection holes in patients and the impact of screw locations and bone mineral density (BMD) on the results. METHODS: This study recruited 40 patients who underwent instrumentation with cement-augmented screws. Screw holes of group A were 4 holes located in the distal one third of screws, while screw holes of group B were 6 holes located in distal, middle, and proximal sites. Postoperative computed tomography images were obtained to evaluate the rate and type of cement leakage and the distribution pattern of cement. The lateral or center position of screw tip, BMD, and T-score were also analyzed for their influence on the results. RESULTS: Of 192 screws, 80 (41.7%) exhibited cement leakage on postoperative computed tomography. The incidence of cement distribution in the posterior half and type B leakage in group B was significantly higher compared with group A. In group A, the probability of cement distribution in the posterior half was significantly increased when the screw was laterally inserted. For both groups, the higher incidence of cement distribution in the posterior half was correlated with lower BMD and T-score. CONCLUSIONS: Our results showed that screws with injection holes closer to the screw tip had higher incidences of distribution in the anterior half of the body and lower incidences of type B leakage. Patients with lower BMD and T-scores should be closely monitored, and a more centered position is recommended for screw insertion.


Assuntos
Cimentos Ósseos , Desenho de Equipamento/normas , Osteoporose/cirurgia , Parafusos Pediculares/normas , Complicações Pós-Operatórias/prevenção & controle , Doenças da Coluna Vertebral/cirurgia , Idoso , Cimentos Ósseos/efeitos adversos , Desenho de Equipamento/métodos , Feminino , Humanos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia , Masculino , Pessoa de Meia-Idade , Osteoporose/diagnóstico por imagem , Parafusos Pediculares/efeitos adversos , Complicações Pós-Operatórias/diagnóstico por imagem , Doenças da Coluna Vertebral/diagnóstico por imagem , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/cirurgia , Tomografia Computadorizada por Raios X/métodos
13.
Drug Deliv ; 29(1): 43-51, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34962225

RESUMO

A prototype reusable large-volume (2 mL) autoinjector (LVAI) was designed to compare injection performance of a novel 27 gauge ultra-thin wall (UTW) pre-filled syringe (PFS) cannula (8 mm external cannula length, 14.4 mm total needle length) against an existing 27 gauge special thin wall (STW) PFS cannula (12.7 mm external cannula length, 19 mm total needle length) across a range of injectate viscosities (2.3-30 cP) in a series of in vivo feasibility studies in swine. The UTW cannula had an approximately 30% greater cross-sectional lumen area than the STW cannula. The target exposed needle length was adjusted to ensure appropriate needle penetration depth and achieve injectate deposition in the subcutaneous (SC) tissue. Delivery time and volume, injection site leakage, injectate depot location, and local tissue effects were examined. The STW and UTW cannulae both provided effective SC delivery of contrast placebo solutions, and were able to accommodate injectate viscosity up to 30 cP without quantifiable leakage from the tissue and with minor tissue effects which resolved within 1-2 hours. Delivery times at each viscosity were significantly different between PFS types with the UTW PFS producing faster delivery times. In a histological substudy of the UTW cannula using injectate viscosities up to 50 cP, injection site reactions were rare and, when present, were of minimal severity. This series of studies demonstrates the feasibility of LVAI SC injection and informs autoinjector and PFS design considerations. Use of a UTW cannula may enable more rapid LVAI injections with minimal tissue effects, especially for higher viscosity formulations.


Assuntos
Cânula , Desenho de Equipamento/métodos , Injeções Subcutâneas/instrumentação , Viscosidade , Animais , Feminino , Reação no Local da Injeção/prevenção & controle , Suínos , Fatores de Tempo
14.
Small Methods ; 5(9): e2100376, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34928064

RESUMO

Nanoscale magnetic systems play a decisive role in areas ranging from biology to spintronics. Although, in principle, THz electron paramagnetic resonance (EPR) provides high-resolution access to their properties, lack of sensitivity has precluded realizing this potential. To resolve this issue, the principle of plasmonic enhancement of electromagnetic fields that is used in electric dipole spectroscopies with great success is exploited, and a new type of resonators for the enhancement of THz magnetic fields in a microscopic volume is proposed. A resonator composed of an array of diabolo antennas with a back-reflecting mirror is designed and fabricated. Simulations and THz EPR measurements demonstrate a 30-fold signal increase for thin film samples. This enhancement factor increases to a theoretical value of 7500 for samples confined to the active region of the antennas. These findings open the door to the elucidation of fundamental processes in nanoscale samples, including junctions in spintronic devices or biological membranes.


Assuntos
Espectroscopia de Ressonância de Spin Eletrônica/instrumentação , Desenho de Equipamento/métodos , Simulação por Computador , Campos Eletromagnéticos , Nanotecnologia
15.
J Mater Sci Mater Med ; 33(1): 3, 2021 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-34940923

RESUMO

Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The "classical" elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even "exotic" for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.


Assuntos
Cerâmica/química , Cerâmica/farmacologia , Materiais Revestidos Biocompatíveis/síntese química , Desenho de Equipamento/tendências , Animais , Fenômenos Biofísicos/efeitos dos fármacos , Regeneração Óssea/efeitos dos fármacos , Regeneração Óssea/fisiologia , Substitutos Ósseos/síntese química , Substitutos Ósseos/química , Substitutos Ósseos/farmacologia , Materiais Revestidos Biocompatíveis/química , Desenho de Equipamento/métodos , Humanos , Íons , Osteogênese/efeitos dos fármacos
16.
Biomacromolecules ; 22(12): 4919-4932, 2021 12 13.
Artigo em Inglês | MEDLINE | ID: mdl-34723502

RESUMO

Implementation of hydrogel precursors in two-photon polymerization (2PP) technology provides promising opportunities in the tissue engineering field thanks to their soft characteristics and similarity to extracellular matrix. Most of the hydrogels, however, are prone to post-fabrication deformations, leading to a mismatch between the computer-aided design and the printed structure. In the present work, we have developed novel synthetic hydrogel precursors to overcome the limitations associated with 2PP processing of conventional hydrogel precursors such as post-processing deformations and a narrow processing window. The precursors are based on a poly(ethylene glycol) backbone containing urethane linkers and are, on average, functionalized with six acrylate terminal groups (three on each terminal group). As a benchmark material, we exploited a precursor with an identical backbone and urethane linkers, albeit functionalized with two acrylate groups, that were reported as state-of-the-art. An in-depth characterization of the hexafunctional precursors revealed a reduced swelling ratio (<0.7) and higher stiffness (>36 MPa Young's modulus) compared to their difunctional analogs. The superior physical properties of the newly developed hydrogels lead to 2PP-based fabrication of stable microstructures with excellent shape fidelity at laser scanning speeds up to at least 90 mm s-1, in contrast with the distorted structures of conventional difunctional precursors. The hydrogel films and microscaffolds revealed a good cell interactivity after functionalization of their surface with a gelatin methacrylamide-based coating. The proposed synthesis strategy provides a one-pot and scalable synthesis of hydrogel building blocks that can overcome the current limitations associated with 2PP fabrication of hydrogel microstructures.


Assuntos
Hidrogéis , Microtecnologia , Engenharia Tecidual , Desenho de Equipamento/métodos , Gelatina/química , Hidrogéis/química , Indústria Manufatureira , Polimerização , Engenharia Tecidual/métodos
17.
Anesthesiology ; 135(6): 951-962, 2021 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-34666348

RESUMO

Respiratory viruses are transmitted via respiratory particles that are emitted when people breath, speak, cough, or sneeze. These particles span the size spectrum from visible droplets to airborne particles of hundreds of nanometers. Barrier face coverings ("cloth masks") and surgical masks are loose-fitting and provide limited protection from airborne particles since air passes around the edges of the mask as well as through the filtering material. Respirators, which fit tightly to the face, provide more effective respiratory protection. Although healthcare workers have relied primarily on disposable filtering facepiece respirators (such as N95) during the COVID-19 pandemic, reusable elastomeric respirators have significant potential advantages for the COVID-19 and future respiratory virus pandemics. However, currently available elastomeric respirators were not designed primarily for healthcare or pandemic use and require further development to improve their suitability for this application. The authors believe that the development, implementation, and stockpiling of improved elastomeric respirators should be an international public health priority.


Assuntos
COVID-19/epidemiologia , Elastômeros/normas , Desenho de Equipamento/normas , Pessoal de Saúde/normas , Exposição Ocupacional/normas , Ventiladores Mecânicos/normas , COVID-19/prevenção & controle , COVID-19/transmissão , Desenho de Equipamento/métodos , Reutilização de Equipamento/normas , Humanos , Exposição Ocupacional/prevenção & controle , Pandemias/prevenção & controle
18.
Plast Reconstr Surg ; 148(5): 1101-1110, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34705785

RESUMO

BACKGROUND: The maxilla position is essential for the aesthetic and functional outcomes of orthognathic surgery. Previous studies demonstrated the advantages of patient-specific implants in orthognathic surgery. However, more data are needed to confirm the superiority of patient-specific implants over surgical splints created with computer-aided design/computer-aided manufacturing (CAD/CAM). This randomized controlled trial aimed to compare the accuracy of patient-specific implants and CAD/CAM splints for maxilla repositioning in orthognathic surgery. METHODS: Patients (n = 64) who required orthognathic surgery were randomly assigned to use either patient-specific implants (patient-specific implant group) or CAD/CAM surgical splints (splint group) to reposition the maxilla. The outcome evaluation was completed by comparing virtual plans with actual results. The primary outcome was the discrepancies of the centroid position of the maxilla. Other translation and orientation discrepancies of the maxilla were also assessed. RESULTS: The authors analyzed 27 patients in the patient-specific implant group and 31 in the splint group. The maxilla position discrepancy was 1.41 ± 0.58 mm in the patient-specific implant group and 2.20 ± 0.94 mm in the splint group; the between-group difference was significant (p < 0.001). For the patient-specific implant group, the largest translation discrepancy was 1.02 ± 0.66 mm in the anteroposterior direction, and the largest orientation discrepancy was 1.85 ± 1.42 degrees in pitch. For the splint group, the largest translation discrepancy was 1.23 ± 0.93 mm in the mediolateral direction, and the largest orientation discrepancy was 1.72 ± 1.56 degrees in pitch. CONCLUSION: The result showed that using patient-specific implants in orthognathic surgery resulted in a more accurate maxilla position than CAD/CAM surgical splints. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, I.


Assuntos
Desenho Assistido por Computador , Desenho de Equipamento/métodos , Má Oclusão/cirurgia , Procedimentos Cirúrgicos Ortognáticos/instrumentação , Contenções , Adulto , Feminino , Humanos , Imageamento Tridimensional , Masculino , Má Oclusão/diagnóstico , Maxila/diagnóstico por imagem , Maxila/cirurgia , Planejamento de Assistência ao Paciente , Resultado do Tratamento , Adulto Jovem
19.
Appl Opt ; 60(21): 6147-6154, 2021 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-34613279

RESUMO

Multifocal lenses comprising progressive power surfaces are commonly used in contact and intraocular lens designs. Given a visual performance metric, a wavefront engineering approach to design such lenses is based on searching for the optimal wavefront at the exit pupil of the eye. Multifocal wavefronts distribute the energy along the different foci thanks to having a varying mean curvature. Therefore, a fundamental step in the wavefront engineering approach is to generate the wavefront from a prescribed mean curvature function. Conventionally, such a thing is done by superimposing spherical wavefront patches and maybe adding a certain component of spherical aberration to each spherical patch in order to increase the depth-of-field associated with each focus. However, such a procedure does not lead to smooth wavefront solutions and also restricts the type of available multifocal wavefronts. We derive a new, to the best of our knowledge, mathematical method to uniquely construct multifocal wavefronts from mean curvature functions (depending on radial and angular coordinates) under certain numerically justified approximations and restrictions. Additionally, our procedure leads to a particular family of wavefronts (line-umbilical multifocal wavefronts) described by 2 conditions: (1) to be smooth multiplicative separable functions in the radial and angular coordinates; (2) to be umbilical along a specific segment connecting the circle center with its edge. We provide several examples of multifocal wavefronts belonging to this family, including a smooth variant of the so-called light sword element.


Assuntos
Lentes de Contato , Lentes Intraoculares Multifocais , Aberrações de Frente de Onda da Córnea , Desenho de Equipamento/métodos , Humanos , Fenômenos Ópticos , Optometria
20.
Sci Rep ; 11(1): 20713, 2021 10 20.
Artigo em Inglês | MEDLINE | ID: mdl-34671041

RESUMO

The aim of this randomized controlled trial was to determine the efficacy of stylet angulation at the holding position during tracheal intubation with a McGRATH MAC videolaryngoscope. Patients were randomized to a group for intubation without stylet angulation at the holding position (non-angulation group) and to a group for intubation with stylet angulation at the holding position (angulation group). The primary outcome was the time for placement of the tracheal tube. Sixty patients were analyzed. The mean (standard deviation) times for tube placement were 21.3 (5.6) s in the non-angulation group and 16.9 (3.8) s in the angulation group (P < 0.001). The scores of operator's perception of difficulty in tube delivery, number of attempts for tube delivery, and degrees of extension, abduction, internal rotation of the right upper arm and extension of the right wrist during tube placement in the angulation group were significantly smaller than those in the non-angulation group (P < 0.001, P = 0.002, P < 0.001, P < 0.001, P < 0.001, P < 0.001, respectively). Our results suggest that stylet angulation at the holding position improves maneuverability of the tracheal tube and enables easy, smooth, and swift tube placement during tracheal intubation with a McGRATH MAC videolaryngoscope.


Assuntos
Intubação Intratraqueal/métodos , Desenho de Equipamento/métodos , Feminino , Humanos , Laringoscópios , Masculino , Pessoa de Meia-Idade , Gravação em Vídeo/métodos
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